"People with depression have more mitochondrial DNA and shorter telomeres than nondepressed people do reports, an international team of researchers reports online April 23 in Current Biology."
The reports link is a technical paper and such a fun dry scientific read.
The good news:
"Experiments with mice showed that these DNA changes are brought on by stress or by stress hormones. Four weeks after scientists stopped stressing the mice, their mitochondrial and telomere DNA had returned to normal. Those results indicate that the molecular changes are reversible."
So it is reversible, this is good news for some friends of mine that suffer at the hands of this demon.
"Researchers also studied DNA from more than 11,000 people to learn whether past stress was responsible for the molecular changes seen in people with depression. Depression was associated with the DNA changes, but having a stressful life was not. For instance, people who had experienced childhood sexual abuse but were not depressed did not have statistically meaningful changes to their DNA compared with people who had no history of abuse. The findings suggest that stress can change DNA but many people can bounce back. Depressed people may have a harder time recovering from the molecular damage. "